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KMID : 0882420060710001095
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Korean Journal of Medicine
2006 Volume.71 No. 0 p.1095 ~ p.1100
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A case of successful treatment of central nervous system (CNS) aspergillosis after hematopoietic stem cell transplantation with voriconazole
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Chung Jong-Won
Yang Deok-Hwan
Kim Sang-Ho
Lee Se-Ryeon
Kim Yeo-Kyeoung
Lee Je-Jung
Kim Hyeoung-Joon
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Abstract
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A 26-year-old man with relapsed chronic myelogenous leukemia following bone marrow transplantation received non-myeloablative stem cell transplantation (NST). After the NST, he complained of neurological deficit, with sustained fever. The brain MRI showed multiple ring-enhanced lesions in the cerebellum, pons and left periventricle. He was diagnosed with CNS aspergillosis from a stereotactic biopsy. Following treatment with voriconazole for 21 days, his follow up brain MRI showed a much regressed lesion, with considerably improved clinical symptoms. We reported a case of cerebral aspergillosis, which was successfully treated with voriconazole following NST.(Korean J Med 71:S1095-S1100, 2006)
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KEYWORD
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Central nervous system aspergillosis, Voriconazole, Non-myeloablative stem cell transplantation (NST)
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